St. Blaise was born to rich and noble parents, and received a Christian education. He was a physician before being consecrated a bishop at a young age.

During the persecution of Licinius, St. Blaise, receiving some divine command, moved from the town, and lived as a hermit in a cave. Wild animals visited, and he healed any that were sick and wounded. One day, a group of hunters gathering wild beasts for the game in the amphitheater discovered St. Blaise and seized him. As he was being taken to the governor Agricolaus, the governor of Cappadocia and Lesser Armenia, St. Blaise encountered a woman whose pig was being seized by a wolf; St. Blaise commanded the wolf to release the pig, and it was freed unhurt.

While in prison, he miraculously cured a small boy who was choking to death on a fishbone lodged in his throat. Also, the woman whose pig had been saved brought St. Blaise candles so that his cell would have light and he could read the sacred Scriptures.

Eventually, Agricolaus condemned St. Blaise for upholding his Christian faith rather than apostatizing. He was tortured with the iron comb (an instrument designed for combing wool but was used here for shredding the skin) and finally beheaded.

By the sixth century, St. Blaise's intercession was invoked for diseases of the throat in the East. As early as the eighth century, records attest to the veneration of St. Blaise in Europe, and he became one of the most popular saints in the spiritual life of the middle Ages. Many altars were dedicated to his honor, and even the Abbey of St. Blaise in southern Germany claimed to have some of his relics.

One reason for St. Blaise's popularity arose from the fact he was a physician who cured, even performing miraculous cures. Thereby, those who were sick, especially with throat ailments, invoked his intercession. Eventually the custom of the blessing of throats arose, whereby the priest held two crossed candles over the heads of the faithful or touched their throats with them while he invoked the prayer of the saint and imparted God's blessing. In our present Roman Ritual, the priest prays, "Through the intercession of St. Blaise, bishop and martyr, may God deliver you from every disease of the throat and from every other illness, in the name of the Father, and of the Son, and of the Holy Spirit." This practice continues in many parishes on St. Blaise's feast day.

While we invoke St. Blaise for his protection against any physical ailment of the throat, we should also ask his protection against any spiritual ailment - profanity, cursing, unkind remarks, detraction or gossip. St. James reminds us, "If a man who does not control his tongue imagines that he is devout, he is self-deceived; his worship is pointless" (1:26) and later, "We use [the tongue] to say, 'Praised be the Lord and Father'; then we use it to curse men, though they are made in the likeness of God. Blessing and curse come out of the same mouth. This ought not to be, my brothers!" (3:9-10). Therefore, may St. Blaise protect us from all evil, physical and spiritual, which may attack the throat.